Skin Cancer Forum, Harbuck, Michael, 10/02/2024

The mutaituion and loss of production-reproduction regulation of three major types of dermal genitive cells is the gerneral pathos vernacularly named skin cancer.  From the many types of specialized cells within the integumentum which are ONLY found in this organ,  the basal epithelial cells, the melanoma producing melanocytes, and the squamous cells of the stratum germionativum are statistically the most forecoming and or reported in the current populations.  
With the organ we now know as the integumentum being both the largest in mass and surface area if is easy to suppose that there would be the most cancer associated to the most number of constantly repsoducing cells which are the CLOSEST to environmental factors which can cause them to go rougue.  
Outilned in the refencece video, as well as a well known medical web-site ( see below ),  three types are currently viewed as the most proliferant.  Basal cell carcinoma, Squamous cell carcinoma, and Melanoma.  
According to the referenced statistics,  around eighty percent of the cases of skin cancer which are DIAGNOSED in the United States of America are of the sub-type from the Basal Cell Carcinima.    Needless to say this is quite a disproportion, so the hypothesis stating that the largest mass and area of environmental exposure , being the FIRST layer of granular mitotic cells, is indeed a feasable thory.  Furthermore, this evidence can also support that the skin is an EXTREMELY good protectant for that which lies beneath it.  Literally and figureativly a sacrificial layer of protection for many animals includign human beings.  
Squamous cell cancer was noted at caancercenter.com to be "the second most common" type of dermal cancer in the U.S.   As these celss are mostly, nearly, or already dead, only producing keratin for abrasion protection and then being thrown away and sloughing off into mite-food, it is fascinating that there is not MORE skin cancer.  
 The msot aggressive and dreaded Melanoma now becomes the third mor prevalant skin cancer.  Perhaps the sheer number of melanocytes combines with the proximity to so many capillaries as well as loose aerolar connective tissue allows the malign cells to transverse over the body like no other disease.   
Volumes can and have been written on these cancers.  Here is not the place nor time to try and map the complex physiology involved.  Just remember that cancer begins with that one cell that is unruly and will not die.  
Some of the previously learned knowledge concerning aging could also be used here to correllate the reasons for the formation of skin cancers in older adults as well.  For example age related DNA degradation may reach a point in a skin cell where the regulatory functions of DNA have stopeed so that lack of one or more factors have allowed faulty DNA to pass through the correction process unnoticed, hereby creating a cancer cell which could then replicate, travel to other regions of the body and metastasize.   Life IS chemiocal replications and chains of events.  
For further reading and inverstigation there are a number of other skin cancers which are interesting including sweat gland cancer, which affects mostly older adults and is very rare,  technically breast cancer is also a form, Merkel cell carcinoma, Skin lymphoma, and the Sebaceous gland carcinoma.  
A very interesting region where skin cancer has become a national crisis is Australia, where there are many public service annoucemnts regarding protecting oneself from the sun.  "Slip, Slap, Slop"  
Slip on a shirt, slap on a hat, and slop on some sunscreen...."   
All in all not bad advice for anyone anyhwere.  

1.  Sweat gland carcinoma. Sweat Gland Carcinoma - an overview | ScienceDirect Topics. (n.d.-b). https://www.sciencedirect.com/topics/medicine-and-dentistry/sweat-gland-carcinoma 

2.  City of Hope. (2022a, June 1). Skin cancer types: Common, rare and more. City of Hope. https://www.cancercenter.com/cancer-types/skin-cancer/types